Fatal Flaws How a Misfolded Protein Baffled Scientists and Changed the Way We Look at the Brain Jay Ingram, Lin Tang (Illustrated by)
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- Format:
- Hardback
- Publication date:
- 19 Mar 2013
- ISBN:
- 9780300189896
- Imprint:
- Yale University Press
- Dimensions:
- 296 pages: 210 x 140 x 25mm
- Illustrations:
- 7 b-w illus.
- Sales territories:
- World excluding Canada
Categories:
Discovered and identified as the cause of mad cow disease only three decades ago, the prion is a protein molecule that, when misshapen in the brain, becomes fatal. Novel and controversial, prions have provoked a scientific revolution. They challenge the very foundations of biology: A disease-causing entity with no genetic material at all? A molecule capable of infecting, multiplying, and killing? This book recounts the birth of prion science and the imaginative detective work scientists have undertaken as they struggle to find the answers to devastating brain diseases from mad cow and Creutzfeldt-Jakob disease to Parkinson’s, Alzheimer’s, Lou Gehrig’s, and others.
“Fatal Flaws provides a fascinating insight into the twists and turns of this new science, highlighting the controversies that surrounded its emergence and the ways it turned the world of research into the causes of neurodegenerative disease inside out.”—Lara Marks, author of Sexual Chemistry: A History of the Contraceptive Pill
“No sterile account of white coated scientists, Ingram tells a ‘who-dunnit’ about one of the most fascinating and improbable tales of medical discovery that involves huge egos, petty quarrels, exotic terrain, governmental cover-ups and ritualized cannibalism.”—Jonathan A. Edlow, MD, author of The Deadly Dinner Party and Other Medical Detective Stories
"Jay Ingram's engrossing book is unbeatable for a balanced understanding of how mad cow disease might relate to other brain ailments. It's clear and concerned but never needlessly alarming."—John Rennie, former editor of Scientific American
Won the Canadian Science Writers' Association Outstanding Canadian Science Book Award for general audience books published in 2012.
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