Mathematical Models in the Biosciences I Michael Frame

Publication date:
27 Jul 2021
Yale University Press
544 pages: 235 x 156mm
250 b-w illus.
Sales territories:

An award-winning professor’s introduction to essential concepts of calculus and mathematical modeling for students in the biosciences

This book introduces mathematical modeling to bioscience students, with first semester calculus as the only prerequisite. It is the first of a two-part series exploring essential concepts of calculus in the context of biological systems. Michael Frame covers the essential ideas and theories of basic calculus while providing examples of how they relate and are applicable to subjects such as chemotherapy and tumor growth, chemical diffusion, allometric scaling, predator-prey relations, nerve impulses, and more. He presents Pearl’s causality calculus to resolve Simpson’s paradox, simple cardiac dynamics models, basic epidemiological models including Ronald Ross’s study of malaria and its epidemic curves, and limit cycles for the glycolysis model. Based on the author’s calculus class at Yale, the book makes concepts of calculus less abstract and more relatable for science majors and premedical students.


Michael Frame retired in 2016 as adjunct professor of mathematics at Yale University. For more than twenty years Frame taught courses on fractal geometry and calculus based on applications in biology and medicine. Amelia Urry and he are the coauthors of Fractal Worlds: Grown, Built, and Imagined.